Inhibition of CHK1 enhances cell death induced by the Bcl-2-selective inhibitor ABT-199 in acute myeloid leukemia cells

Resistance to standard chemotherapy agents remains a major obstacle for improving treatment outcomes for acute myeloid leukemia (AML). The Bcl-2-selective inhibitor ABT-199 has demonstrated encouraging preclinical results, drug resistance remains a concern. Mcl-1 has been demonstrated to contribute...

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Опубликовано в: :Oncotarget
Главные авторы: Zhao, Jianyun, Niu, Xiaojia, Li, Xinyu, Edwards, Holly, Wang, Guan, Wang, Yue, Taub, Jeffrey W, Lin, Hai, Ge, Yubin
Формат: Artigo
Язык:Inglês
Опубликовано: Impact Journals LLC 2016
Предметы:
Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5085189/
https://ncbi.nlm.nih.gov/pubmed/27166183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9185
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