Inhibition of Mcl-1 enhances cell death induced by the Bcl-2-selective inhibitor ABT-199 in acute myeloid leukemia cells

Acute myeloid leukemia (AML) is a serious disease. The 5-year survival rates remain frustratingly low (65% for children and 26% for adults). Resistance to frontline chemotherapy (usually cytarabine) often develops; therefore a new treatment modality is needed. Bcl-2 family proteins play an important...

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Publicado no:Signal Transduct Target Ther
Main Authors: Luedtke, Daniel A, Niu, Xiaojia, Pan, Yihang, Zhao, Jianyun, Liu, Shuang, Edwards, Holly, Chen, Kang, Lin, Hai, Taub, Jeffrey W, Ge, Yubin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5661618/
https://ncbi.nlm.nih.gov/pubmed/29263915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sigtrans.2017.12
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