Inhibition of XPO1 enhances cell death induced by ABT‐199 in acute myeloid leukaemia via Mcl‐1

The antiapoptotic Bcl‐2 family proteins play critical roles in resistance to chemotherapy in acute myeloid leukaemia (AML). The Bcl‐2‐selective inhibitor ABT‐199 (Venetoclax) shows promising antileukaemic activity against AML, though Mcl‐1 limits its antileukaemic activity. XPO1 is a nuclear exporte...

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Detalhes bibliográficos
Publicado no:J Cell Mol Med
Main Authors: Luedtke, Daniel A., Su, Yongwei, Liu, Shuang, Edwards, Holly, Wang, Yue, Lin, Hai, Taub, Jeffrey W., Ge, Yubin
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237582/
https://ncbi.nlm.nih.gov/pubmed/30596398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.13886
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