Binding of released Bim to Mcl-1 is a mechanism of intrinsic resistance to ABT-199 which can be overcome by combination with daunorubicin or cytarabine in AML cells

PURPOSE: To investigate the molecular mechanism underlying intrinsic resistance to ABT-199. EXPERIMENTAL DESIGN: Western blots and real-time RT-PCR were used to determine levels of Mcl-1 after ABT-199 treatment alone or in combination with cytarabine or daunorubicin. Immunoprecipitation of Bim and M...

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Udgivet i:Clin Cancer Res
Main Authors: Niu, Xiaojia, Zhao, Jianyun, Ma, Jun, Xie, Chengzhi, Edwards, Holly, Wang, Guan, Caldwell, J. Timothy, Xiang, Shengyan, Zhang, Xiaohong, Chu, Roland, Wang, Zhihong, Lin, Hai, Taub, Jeffrey W., Ge, Yubin
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5010519/
https://ncbi.nlm.nih.gov/pubmed/27103402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-3057
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