Inhibition of XPO1 enhances cell death induced by ABT‐199 in acute myeloid leukaemia via Mcl‐1

The antiapoptotic Bcl‐2 family proteins play critical roles in resistance to chemotherapy in acute myeloid leukaemia (AML). The Bcl‐2‐selective inhibitor ABT‐199 (Venetoclax) shows promising antileukaemic activity against AML, though Mcl‐1 limits its antileukaemic activity. XPO1 is a nuclear exporte...

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Bibliografische gegevens
Gepubliceerd in:J Cell Mol Med
Hoofdauteurs: Luedtke, Daniel A., Su, Yongwei, Liu, Shuang, Edwards, Holly, Wang, Yue, Lin, Hai, Taub, Jeffrey W., Ge, Yubin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2018
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Original Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237582/
https://ncbi.nlm.nih.gov/pubmed/30596398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.13886
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