Ex vivo lung perfusion as a human platform for preclinical small molecule testing

The acute respiratory distress syndrome (ARDS) causes an estimated 70,000 US deaths annually. Multiple pharmacologic interventions for ARDS have been tested and failed. An unmet need is a suitable laboratory human model to predictively assess emerging therapeutics on organ function in ARDS. We previ...

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Vydáno v:JCI Insight
Hlavní autoři: Weathington, Nathaniel M., Álvarez, Diana, Sembrat, John, Radder, Josiah, Cárdenes, Nayra, Noda, Kentaro, Gong, Qiaoke, Wong, Hesper, Kolls, Jay, D’Cunha, Jonathan, Mallampalli, Rama K., Chen, Bill B., Rojas, Mauricio
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2018
Témata:
Technical Advance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237445/
https://ncbi.nlm.nih.gov/pubmed/30282819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.95515
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