Ex vivo lung perfusion as a human platform for preclinical small molecule testing

The acute respiratory distress syndrome (ARDS) causes an estimated 70,000 US deaths annually. Multiple pharmacologic interventions for ARDS have been tested and failed. An unmet need is a suitable laboratory human model to predictively assess emerging therapeutics on organ function in ARDS. We previ...

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Veröffentlicht in:JCI Insight
Hauptverfasser: Weathington, Nathaniel M., Álvarez, Diana, Sembrat, John, Radder, Josiah, Cárdenes, Nayra, Noda, Kentaro, Gong, Qiaoke, Wong, Hesper, Kolls, Jay, D’Cunha, Jonathan, Mallampalli, Rama K., Chen, Bill B., Rojas, Mauricio
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2018
Schlagworte:
Technical Advance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237445/
https://ncbi.nlm.nih.gov/pubmed/30282819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.95515
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