Ex vivo lung perfusion as a human platform for preclinical small molecule testing

The acute respiratory distress syndrome (ARDS) causes an estimated 70,000 US deaths annually. Multiple pharmacologic interventions for ARDS have been tested and failed. An unmet need is a suitable laboratory human model to predictively assess emerging therapeutics on organ function in ARDS. We previ...

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Bibliografiske detaljer
Udgivet i:JCI Insight
Main Authors: Weathington, Nathaniel M., Álvarez, Diana, Sembrat, John, Radder, Josiah, Cárdenes, Nayra, Noda, Kentaro, Gong, Qiaoke, Wong, Hesper, Kolls, Jay, D’Cunha, Jonathan, Mallampalli, Rama K., Chen, Bill B., Rojas, Mauricio
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2018
Fag:
Technical Advance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237445/
https://ncbi.nlm.nih.gov/pubmed/30282819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.95515
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