Ex vivo lung perfusion as a human platform for preclinical small molecule testing

The acute respiratory distress syndrome (ARDS) causes an estimated 70,000 US deaths annually. Multiple pharmacologic interventions for ARDS have been tested and failed. An unmet need is a suitable laboratory human model to predictively assess emerging therapeutics on organ function in ARDS. We previ...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Weathington, Nathaniel M., Álvarez, Diana, Sembrat, John, Radder, Josiah, Cárdenes, Nayra, Noda, Kentaro, Gong, Qiaoke, Wong, Hesper, Kolls, Jay, D’Cunha, Jonathan, Mallampalli, Rama K., Chen, Bill B., Rojas, Mauricio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Technical Advance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237445/
https://ncbi.nlm.nih.gov/pubmed/30282819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.95515
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