Combination anti–PD-1 and antiretroviral therapy provides therapeutic benefit against SIV

Therapeutic strategies that augment antiviral immunity and reduce the viral reservoir are critical to achieving durable remission of HIV. The coinhibitory receptor programmed death-1 (PD-1) regulates CD8(+) T cell dysfunction during chronic HIV and SIV infections. We previously demonstrated that in...

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Dettagli Bibliografici
Pubblicato in:JCI Insight
Autori principali: Mylvaganam, Geetha H., Chea, Lynette S., Tharp, Gregory K., Hicks, Sakeenah, Velu, Vijayakumar, Iyer, Smita S., Deleage, Claire, Estes, Jacob D., Bosinger, Steven E., Freeman, Gordon J., Ahmed, Rafi, Amara, Rama R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2018
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237231/
https://ncbi.nlm.nih.gov/pubmed/30232277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.122940
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