Combination anti–PD-1 and antiretroviral therapy provides therapeutic benefit against SIV

Therapeutic strategies that augment antiviral immunity and reduce the viral reservoir are critical to achieving durable remission of HIV. The coinhibitory receptor programmed death-1 (PD-1) regulates CD8(+) T cell dysfunction during chronic HIV and SIV infections. We previously demonstrated that in...

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Veröffentlicht in:JCI Insight
Hauptverfasser: Mylvaganam, Geetha H., Chea, Lynette S., Tharp, Gregory K., Hicks, Sakeenah, Velu, Vijayakumar, Iyer, Smita S., Deleage, Claire, Estes, Jacob D., Bosinger, Steven E., Freeman, Gordon J., Ahmed, Rafi, Amara, Rama R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237231/
https://ncbi.nlm.nih.gov/pubmed/30232277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.122940
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