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PD-1 blockade during chronic SIV infection reduces hyperimmune activation and microbial translocation in rhesus macaques
Hyperimmune activation is a strong predictor of disease progression during pathogenic immunodeficiency virus infections and is mediated in part by sustained type I IFN signaling in response to adventitious microbial infection. The immune inhibitory receptor programmed death–1 (PD-1) regulates functi...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Clinical Investigation
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3336983/ https://ncbi.nlm.nih.gov/pubmed/22523065 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI60612 |
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