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PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques
Boosting immune cell function by targeting the co-inhibitory receptor PD-1 may have applications in the treatment of chronic infections. Here we examine the role of PD-1 during Mycobacterium tuberculosis (Mtb) infection of rhesus macaques. Animals treated with anti-PD-1 monoclonal antibody developed...
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| Veröffentlicht in: | Sci Immunol |
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8300572/ https://ncbi.nlm.nih.gov/pubmed/33452107 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.abf3861 |
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