PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques

Boosting immune cell function by targeting the co-inhibitory receptor PD-1 may have applications in the treatment of chronic infections. Here we examine the role of PD-1 during Mycobacterium tuberculosis (Mtb) infection of rhesus macaques. Animals treated with anti-PD-1 monoclonal antibody developed...

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Veröffentlicht in:Sci Immunol
Hauptverfasser: Kauffman, Keith D, Sakai, Shunsuke, Lora, Nickiana E, Namasivayam, Sivaranjani, Baker, Paul J, Kamenyeva, Olena, Foreman, Taylor W, Nelson, Christine E, Oliveira-de-Souza, Deivide, Vinhaes, Caian L., Yaniv, Ziv, Lindestam Arleham, Cecilia S, Sette, Alessandro, Freeman, Gordon J, Moore, Rashida, Sher, Alan, Mayer-Barber, Katrin D, Andrade, Bruno B, Kabat, Juraj, Via, Laura E, Barber, Daniel L
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8300572/
https://ncbi.nlm.nih.gov/pubmed/33452107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.abf3861
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