PD-1 blockade during chronic SIV infection reduces hyperimmune activation and microbial translocation in rhesus macaques

Hyperimmune activation is a strong predictor of disease progression during pathogenic immunodeficiency virus infections and is mediated in part by sustained type I IFN signaling in response to adventitious microbial infection. The immune inhibitory receptor programmed death–1 (PD-1) regulates functi...

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Autori principali: Dyavar Shetty, Ravi, Velu, Vijayakumar, Titanji, Kehmia, Bosinger, Steven E., Freeman, Gordon J., Silvestri, Guido, Amara, Rama Rao
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2012
Soggetti:
Brief Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3336983/
https://ncbi.nlm.nih.gov/pubmed/22523065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI60612
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