A novel lysosome‐to‐mitochondria signaling pathway disrupted by amyloid‐β oligomers

The mechanisms of mitochondrial dysfunction in Alzheimer's disease are incompletely understood. Using two‐photon fluorescence lifetime microscopy of the coenzymes, NADH and NADPH, and tracking brain oxygen metabolism with multi‐parametric photoacoustic microscopy, we show that activation of lys...

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Pubblicato in:EMBO J
Autori principali: Norambuena, Andrés, Wallrabe, Horst, Cao, Rui, Wang, Dora Bigler, Silva, Antonia, Svindrych, Zdenek, Periasamy, Ammasi, Hu, Song, Tanzi, Rudolph E, Kim, Doo Yeon, Bloom, George S
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2018
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6236329/
https://ncbi.nlm.nih.gov/pubmed/30348864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2018100241
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