A novel lysosome‐to‐mitochondria signaling pathway disrupted by amyloid‐β oligomers

The mechanisms of mitochondrial dysfunction in Alzheimer's disease are incompletely understood. Using two‐photon fluorescence lifetime microscopy of the coenzymes, NADH and NADPH, and tracking brain oxygen metabolism with multi‐parametric photoacoustic microscopy, we show that activation of lys...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Norambuena, Andrés, Wallrabe, Horst, Cao, Rui, Wang, Dora Bigler, Silva, Antonia, Svindrych, Zdenek, Periasamy, Ammasi, Hu, Song, Tanzi, Rudolph E, Kim, Doo Yeon, Bloom, George S
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6236329/
https://ncbi.nlm.nih.gov/pubmed/30348864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2018100241
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