A novel lysosome‐to‐mitochondria signaling pathway disrupted by amyloid‐β oligomers

The mechanisms of mitochondrial dysfunction in Alzheimer's disease are incompletely understood. Using two‐photon fluorescence lifetime microscopy of the coenzymes, NADH and NADPH, and tracking brain oxygen metabolism with multi‐parametric photoacoustic microscopy, we show that activation of lys...

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Bibliographic Details
Published in:EMBO J
Main Authors: Norambuena, Andrés, Wallrabe, Horst, Cao, Rui, Wang, Dora Bigler, Silva, Antonia, Svindrych, Zdenek, Periasamy, Ammasi, Hu, Song, Tanzi, Rudolph E, Kim, Doo Yeon, Bloom, George S
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6236329/
https://ncbi.nlm.nih.gov/pubmed/30348864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2018100241
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