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Filter Retardation Assay for Detecting and Quantifying Polyglutamine Aggregates Using Caenorhabditis elegans Lysates

Protein aggregation is a hallmark of several neurodegenerative diseases and is associated with impaired protein homeostasis. This imbalance is caused by the loss of the protein’s native conformation, which ultimately results in its aggregation or abnormal localization within the cell. Using a C. ele...

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Bibliografski detalji
Izdano u:Bio Protoc
Glavni autori: Sin, Olga, Mata-Cabana, Alejandro, Seinstra, Renée I., Nollen, Ellen A. A.
Format: Artigo
Jezik:Inglês
Izdano: Bio-Protocol 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6235101/
https://ncbi.nlm.nih.gov/pubmed/30450365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21769/BioProtoc.3042
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