Filter Retardation Assay for Detecting and Quantifying Polyglutamine Aggregates Using Caenorhabditis elegans Lysates

Protein aggregation is a hallmark of several neurodegenerative diseases and is associated with impaired protein homeostasis. This imbalance is caused by the loss of the protein’s native conformation, which ultimately results in its aggregation or abnormal localization within the cell. Using a C. ele...

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Bibliographic Details
Published in:Bio Protoc
Main Authors: Sin, Olga, Mata-Cabana, Alejandro, Seinstra, Renée I., Nollen, Ellen A. A.
Format: Artigo
Language:Inglês
Published: Bio-Protocol 2018
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Methods Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6235101/
https://ncbi.nlm.nih.gov/pubmed/30450365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21769/BioProtoc.3042
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