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Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease by using an automated filter retardation assay

Preventing the formation of insoluble polyglutamine containing protein aggregates in neurons may represent an attractive therapeutic strategy to ameliorate Huntington's disease (HD). Therefore, the ability to screen for small molecules that suppress the self-assembly of huntingtin would have potenti...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Heiser, Volker, Engemann, Sabine, Bröcker, Wolfgang, Dunkel, Ilona, Boeddrich, Annett, Waelter, Stephanie, Nordhoff, Eddi, Lurz, Rudi, Schugardt, Nancy, Rautenberg, Susanne, Herhaus, Christian, Barnickel, Gerhard, Böttcher, Henning, Lehrach, Hans, Wanker, Erich E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2002
Assuntos:
Colloquium Paper
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC139900/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12200548/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.182426599
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