Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease by using an automated filter retardation assay

Preventing the formation of insoluble polyglutamine containing protein aggregates in neurons may represent an attractive therapeutic strategy to ameliorate Huntington's disease (HD). Therefore, the ability to screen for small molecules that suppress the self-assembly of huntingtin would have po...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Heiser, Volker, Engemann, Sabine, Bröcker, Wolfgang, Dunkel, Ilona, Boeddrich, Annett, Waelter, Stephanie, Nordhoff, Eddi, Lurz, Rudi, Schugardt, Nancy, Rautenberg, Susanne, Herhaus, Christian, Barnickel, Gerhard, Böttcher, Henning, Lehrach, Hans, Wanker, Erich E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The National Academy of Sciences 2002
Konular:
Colloquium Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC139900/
https://ncbi.nlm.nih.gov/pubmed/12200548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.182426599
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller