Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease by using an automated filter retardation assay

Preventing the formation of insoluble polyglutamine containing protein aggregates in neurons may represent an attractive therapeutic strategy to ameliorate Huntington's disease (HD). Therefore, the ability to screen for small molecules that suppress the self-assembly of huntingtin would have potenti...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Heiser, Volker, Engemann, Sabine, Bröcker, Wolfgang, Dunkel, Ilona, Boeddrich, Annett, Waelter, Stephanie, Nordhoff, Eddi, Lurz, Rudi, Schugardt, Nancy, Rautenberg, Susanne, Herhaus, Christian, Barnickel, Gerhard, Böttcher, Henning, Lehrach, Hans, Wanker, Erich E.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2002
Soggetti:	Colloquium Paper
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC139900/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12200548/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.182426599
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