Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease by using an automated filter retardation assay

Preventing the formation of insoluble polyglutamine containing protein aggregates in neurons may represent an attractive therapeutic strategy to ameliorate Huntington's disease (HD). Therefore, the ability to screen for small molecules that suppress the self-assembly of huntingtin would have po...

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Hlavní autoři: Heiser, Volker, Engemann, Sabine, Bröcker, Wolfgang, Dunkel, Ilona, Boeddrich, Annett, Waelter, Stephanie, Nordhoff, Eddi, Lurz, Rudi, Schugardt, Nancy, Rautenberg, Susanne, Herhaus, Christian, Barnickel, Gerhard, Böttcher, Henning, Lehrach, Hans, Wanker, Erich E.
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 2002
Témata:
Colloquium Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC139900/
https://ncbi.nlm.nih.gov/pubmed/12200548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.182426599
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