HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury

BACKGROUND: In muscular dystrophy and old age, skeletal muscle repair is compromised leading to fibrosis and fatty tissue accumulation. Therefore, therapies that protect skeletal muscle or enhance repair would be valuable medical treatments. Hypoxia-inducible factors (HIFs) regulate gene transcripti...

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Pubblicato in:Skelet Muscle
Autori principali: Billin, Andrew N., Honeycutt, Samuel E., McDougal, Alan V., Kerr, Jaclyn P., Chen, Zhe, Freudenberg, Johannes M., Rajpal, Deepak K., Luo, Guizhen, Kramer, Henning Fritz, Geske, Robert S., Fang, Frank, Yao, Bert, Clark, Richard V., Lepore, John, Cobitz, Alex, Miller, Ram, Nosaka, Kazunori, Hinken, Aaron C., Russell, Alan J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2018
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6234580/
https://ncbi.nlm.nih.gov/pubmed/30424786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13395-018-0179-5
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