HIF-independent role of prolyl hydroxylases in the cellular response to amino acids

Hypoxia-inducible factor (HIF) prolyl hydroxylases (PHDs) are α-ketoglutarate (αKG)-dependent dioxygenases that function as cellular oxygen sensors. However, PHD activity also depends on factors other than oxygen, especially αKG, a key metabolic compound closely linked to amino-acid metabolism. We e...

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Detalhes bibliográficos
Main Authors: Durán, R V, MacKenzie, E D, Boulahbel, H, Frezza, C, Heiserich, L, Tardito, S, Bussolati, O, Rocha, S, Hall, M N, Gottlieb, E
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3787797/
https://ncbi.nlm.nih.gov/pubmed/23085753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.465
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