HIF-independent role of prolyl hydroxylases in the cellular response to amino acids

Por Durán, R V, MacKenzie, E D, Boulahbel, H, Frezza, C, Heiserich, L, Tardito, S, Bussolati, O, Rocha, S, Hall, M N, Gottlieb, E
Publicado em 2013

Protection against cardiac ischemia-reperfusion injury by hypothermia and by inhibition of succinate accumulation and oxidation is additive

Por Kohlhauer, M., Pell, V. R., Burger, N., Spiroski, A. M., Gruszczyk, A., Mulvey, J. F., Mottahedin, Amin, Costa, A. S. H., Frezza, C., Ghaleh, B., Murphy, M. P., Tissier, R., Krieg, T.
Publicado no Basic Res Cardiol (2019)

Repurposing mitochondria from ATP production to ROS generation drives a pro-inflammatory phenotype in macrophages that depends on succinate oxidation by complex II

Por Mills, E. L., Kelly, B., Logan, A, Costa, A. S. H., Varma, M., Bryant, C. E., Tourlomousis, P., Däbritz, J. H. M., Gottlieb, E., Latorre, I., Corr, S.C., McManus, G., Ryan, D., Jacobs, H.T., Szibor, M., Xavier, R. J., Braun, T., Frezza, C., Murphy, M. P., O’Neill, L. A.
Publicado no Cell (2016)

Succinate is a danger signal that induces IL-1β via HIF-1α

Por Tannahill, GM, Curtis, AM, Adamik, J, Palsson-McDermott, EM, McGettrick, AF, Goel, G, Frezza, C, Bernard, NJ, Kelly, B, Foley, NH, Zheng, L, Gardet, A, Tong, Z, Jany, SS, Corr, SC, Haneklaus, M, Caffery, BE, Pierce, K, Walmsley, S, Beasley, FC, Cummins, E, Nizet, V, Whyte, M, Taylor, CT, Lin, H, Masters, SL, Gottlieb, E, Kelly, VP, Clish, C, Auron, PE, Xavier, RJ, O’Neill, LAJ
Publicado em 2013