Repurposing mitochondria from ATP production to ROS generation drives a pro-inflammatory phenotype in macrophages that depends on succinate oxidation by complex II

Por Mills, E. L., Kelly, B., Logan, A, Costa, A. S. H., Varma, M., Bryant, C. E., Tourlomousis, P., Däbritz, J. H. M., Gottlieb, E., Latorre, I., Corr, S.C., McManus, G., Ryan, D., Jacobs, H.T., Szibor, M., Xavier, R. J., Braun, T., Frezza, C., Murphy, M. P., O’Neill, L. A.
Publicado no Cell (2016)

Succinate is a danger signal that induces IL-1β via HIF-1α

Por Tannahill, GM, Curtis, AM, Adamik, J, Palsson-McDermott, EM, McGettrick, AF, Goel, G, Frezza, C, Bernard, NJ, Kelly, B, Foley, NH, Zheng, L, Gardet, A, Tong, Z, Jany, SS, Corr, SC, Haneklaus, M, Caffery, BE, Pierce, K, Walmsley, S, Beasley, FC, Cummins, E, Nizet, V, Whyte, M, Taylor, CT, Lin, H, Masters, SL, Gottlieb, E, Kelly, VP, Clish, C, Auron, PE, Xavier, RJ, O’Neill, LAJ
Publicado em 2013