Hyperoxia attenuates the inhibitory effect of nitric oxide donors on HIF prolyl-4-hydroxylase-2: Implication on discriminative effect of nitric oxide on HIF prolyl-4-hydroxylase-2 and collagen prolyl-4-hydroxylase

Prolyl 4-hydroxylases (P4Hs), such as collagen prolyl-4-hydroxylases (CPHs) and hypoxia inducible factor prolyl-4-hydroxylases (HPHs), have recently been recognized as promising drug targets for the treatment of fibrotic and ischemic diseases. CPHs and HPHs catalyze identical metabolic reactions, ye...

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Main Authors: Yum, Soohwan, Choi, Jeongyoun, Hong, Sungchae, Park, Myung Hee, Lee, Jaewon, Ha, Nam-Chul, Jung, Yunjin
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3994879/
https://ncbi.nlm.nih.gov/pubmed/21723853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2011.05.033
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