Benzimidazole-2-pyrazole HIF Prolyl 4-Hydroxylase Inhibitors as Oral Erythropoietin Secretagogues

[Image: see text] HIF prolyl 4-hydroxylases (PHD) are a family of enzymes that mediate key physiological responses to hypoxia by modulating the levels of hypoxia inducible factor 1-α (HIF1α). Certain benzimidazole-2-pyrazole carboxylates were discovered to be PHD2 inhibitors using ligand- and struct...

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Autori principali: Rosen, Mark D., Venkatesan, Hariharan, Peltier, Hillary M., Bembenek, Scott D., Kanelakis, Kimon C., Zhao, Lucy X., Leonard, Barry E., Hocutt, Frances M., Wu, Xiaodong, Palomino, Heather L., Brondstetter, Theresa I., Haugh, Peter V., Cagnon, Laurence, Yan, Wen, Liotta, Lisa A., Young, Andrew, Mirzadegan, Tara, Shankley, Nigel P., Barrett, Terrance D., Rabinowitz, Michael H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2010
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007848/
https://ncbi.nlm.nih.gov/pubmed/24900242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100198y
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