Functional Characterization of the Canine Heme-Regulated eIF2α Kinase: Regulation of Protein Synthesis

The heme-regulated inhibitor (HRI) negatively regulates protein synthesis by phosphorylating eukaryotic initiation factor-2α (eIF2α) thereby inhibiting protein translation. The importance of HRI in regulating hemoglobin synthesis in erythroid cells makes it an attractive molecular target in need of...

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Autori principali: Kanelakis, Kimon C., Pyati, Jayashree, Wagaman, Pamela C., Chuang, Jui Chang, Yang, Young, Shankley, Nigel P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi Publishing Corporation 2009
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2778829/
https://ncbi.nlm.nih.gov/pubmed/19946423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2009/251915
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