The eIF2α Kinase Heme-Regulated Inhibitor Protects the Host from Infection by Regulating Intracellular Pathogen Trafficking

The host employs both cell-autonomous and system-level responses to limit pathogen replication in the initial stages of infection. Previously, we reported that the eukaryotic initiation factor 2α (eIF2α) kinases heme-regulated inhibitor (HRI) and protein kinase R (PKR) control distinct cellular and...

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Pubblicato in:Infect Immun
Autori principali: Bahnan, Wael, Boucher, Justin C., Gayle, Petoria, Shrestha, Niraj, Rosen, Mark, Aktas, Bertal, Adkins, Becky, Ager, Arba, Khan, Wasif N., Schesser, Kurt
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2018
Soggetti:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5820965/
https://ncbi.nlm.nih.gov/pubmed/29311243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00707-17
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