Perforin-2 Protects Host Cells and Mice by Restricting the Vacuole to Cytosol Transitioning of a Bacterial Pathogen

The host-encoded Perforin-2 (encoded by the macrophage-expressed gene 1, Mpeg1), which possesses a pore-forming MACPF domain, reduces the viability of bacterial pathogens that reside within membrane-bound compartments. Here, it is shown that Perforin-2 also restricts the proliferation of the intracy...

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: McCormack, Ryan, Bahnan, Wael, Shrestha, Niraj, Boucher, Justin, Barreto, Marcella, Barrera, Carlos M., Dauer, Edward A., Freitag, Nancy E., Khan, Wasif N., Podack, Eckhard R., Schesser, Kurt
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4807494/
https://ncbi.nlm.nih.gov/pubmed/26831467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01434-15
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