HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury

BACKGROUND: In muscular dystrophy and old age, skeletal muscle repair is compromised leading to fibrosis and fatty tissue accumulation. Therefore, therapies that protect skeletal muscle or enhance repair would be valuable medical treatments. Hypoxia-inducible factors (HIFs) regulate gene transcripti...

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Detalhes bibliográficos
Publicado no:Skelet Muscle
Main Authors: Billin, Andrew N., Honeycutt, Samuel E., McDougal, Alan V., Kerr, Jaclyn P., Chen, Zhe, Freudenberg, Johannes M., Rajpal, Deepak K., Luo, Guizhen, Kramer, Henning Fritz, Geske, Robert S., Fang, Frank, Yao, Bert, Clark, Richard V., Lepore, John, Cobitz, Alex, Miller, Ram, Nosaka, Kazunori, Hinken, Aaron C., Russell, Alan J.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6234580/
https://ncbi.nlm.nih.gov/pubmed/30424786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13395-018-0179-5
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