Widespread selection for oncogenic mutant allele imbalance in cancer

Driver mutations in oncogenes encode proteins with gain-of-function properties that enhance fitness. Heterozygous mutations are thus viewed as sufficient for tumorigenesis. We describe widespread oncogenic mutant allele imbalance in 13,448 prospectively characterized cancers. Imbalance was selected...

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Gepubliceerd in:Cancer Cell
Hoofdauteurs: Bielski, Craig M., Donoghue, Mark T.A., Gadiya, Mayur, Hanrahan, Aphrothiti J., Won, Helen H., Chang, Matthew T., Jonsson, Philip, Penson, Alexander V., Gorelick, Alexander, Harris, Christopher, Schram, Alison M., Syed, Aijazuddin, Zehir, Ahmet, Chapman, Paul B., Hyman, David M., Solit, David B., Shannon, Kevin, Chandarlapaty, Sarat, Berger, Michael F., Taylor, Barry S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6234065/
https://ncbi.nlm.nih.gov/pubmed/30393068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.10.003
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