Dual gain and loss of cullin 3 function mediates familial hyperkalemic hypertension

Familial hyperkalemic hypertension is caused by mutations in with-no-lysine kinases (WNKs) or in proteins that mediate their degradation, kelch-like 3 (KLHL3) and cullin 3 (CUL3). Although the mechanisms by which WNK and KLHL3 mutations cause the disease are now clear, the effects of the disease-cau...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Am J Physiol Renal Physiol
Prif Awduron: Cornelius, Ryan J., Zhang, Chong, Erspamer, Kayla J., Agbor, Larry N., Sigmund, Curt D., Singer, Jeffrey D., Yang, Chao-Ling, Ellison, David H.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Physiological Society 2018
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6230741/
https://ncbi.nlm.nih.gov/pubmed/29897280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00602.2017
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