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The helicase Ded1p controls use of near-cognate translation initiation codons in 5′UTRs
The conserved and essential DEAD-box RNA helicase Ded1p from yeast and its mammalian ortholog DDX3 are critical for translation initiation(1). Mutations in DDX3 are linked to tumorigenesis(2–4) and intellectual disability(5), and the enzyme is targeted by diverse viruses(6). How Ded1p and its orthol...
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| 出版年: | Nature |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6226265/ https://ncbi.nlm.nih.gov/pubmed/29950728 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0258-0 |
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