The helicase Ded1p controls use of near-cognate translation initiation codons in 5′UTRs

The conserved and essential DEAD-box RNA helicase Ded1p from yeast and its mammalian ortholog DDX3 are critical for translation initiation(1). Mutations in DDX3 are linked to tumorigenesis(2–4) and intellectual disability(5), and the enzyme is targeted by diverse viruses(6). How Ded1p and its orthol...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Nature
Autori principali: Guenther, Ulf-Peter, Weinberg, David E., Zubradt, Meghan M., Tedeschi, Frank A., Stawicki, Brittany N., Zagore, Leah L., Brar, Gloria A., Licatalosi, Donny D., Bartel, David P., Weissman, Jonathan S., Jankowsky, Eckhard
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6226265/
https://ncbi.nlm.nih.gov/pubmed/29950728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0258-0
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi