The helicase Ded1p controls use of near-cognate translation initiation codons in 5′UTRs

The conserved and essential DEAD-box RNA helicase Ded1p from yeast and its mammalian ortholog DDX3 are critical for translation initiation(1). Mutations in DDX3 are linked to tumorigenesis(2–4) and intellectual disability(5), and the enzyme is targeted by diverse viruses(6). How Ded1p and its orthol...

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Publicado no:Nature
Main Authors: Guenther, Ulf-Peter, Weinberg, David E., Zubradt, Meghan M., Tedeschi, Frank A., Stawicki, Brittany N., Zagore, Leah L., Brar, Gloria A., Licatalosi, Donny D., Bartel, David P., Weissman, Jonathan S., Jankowsky, Eckhard
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6226265/
https://ncbi.nlm.nih.gov/pubmed/29950728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0258-0
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