Kinase domain activation through gene rearrangement in multiple myeloma

Chromosomal rearrangements that result in oncogenic kinase activation are present in many solid and hematological malignancies, but none have been reported in multiple myeloma (MM). Here we analyzed 1421 samples from 958 myeloma patients using a targeted assay and detected fusion genes in 1.5% of pa...

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Udgivet i:Leukemia
Main Authors: Morgan, Gareth J, He, Jie, Tytarenko, Ruslana, Patel, Purvi, Stephens, Owen W, Zhong, Shan, Deshpande, Shayu, Bauer, Michael, Weinhold, Niels, Schinke, Carolina, Rasche, Leo, Bailey, Mark, Ali, Siraj, Ross, Jeff, Miller, Vincent A, Stephens, Phillip, Thanendrarajan, Sharmilan, Zangari, Maurizio, van Rhee, Frits, Mughal, Tariq, Davies, Faith E, Walker, Brian A
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6224403/
https://ncbi.nlm.nih.gov/pubmed/29654269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-018-0108-y
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