Clonal selection and double-hit events involving tumor suppressor genes underlie relapse in myeloma

To elucidate the mechanisms underlying relapse from chemotherapy in multiple myeloma, we performed a longitudinal study of 33 patients entered into Total Therapy protocols investigating them using gene expression profiling, high-resolution copy number arrays, and whole-exome sequencing. The study il...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Weinhold, Niels, Ashby, Cody, Rasche, Leo, Chavan, Shweta S., Stein, Caleb, Stephens, Owen W., Tytarenko, Ruslana, Bauer, Michael A., Meissner, Tobias, Deshpande, Shayu, Patel, Purvi H., Buzder, Timea, Molnar, Gabor, Peterson, Erich A., van Rhee, Frits, Zangari, Maurizio, Thanendrarajan, Sharmilan, Schinke, Carolina, Tian, Erming, Epstein, Joshua, Barlogie, Bart, Davies, Faith E., Heuck, Christoph J., Walker, Brian A, Morgan, Gareth J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2016
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5043128/
https://ncbi.nlm.nih.gov/pubmed/27516441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-06-723007
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