Poor overall survival in hyperhaploid multiple myeloma is defined by double-hit bi-allelic inactivation of TP53

Hyperhaploid multiple myeloma is a rare numerical aberration group defined by a range of 24-34 chromosomes, which is associated with a poor prognosis with a 5-year survival rate of 23%. Hyperhaploid patient samples (n=8) were sequenced and copy number and mutations identified. Samples had a median o...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Ashby, Cody, Tytarenko, Ruslana G., Wang, Yan, Weinhold, Niels, Johnson, Sarah K., Bauer, Michael, Wardell, Christopher P., Schinke, Carolina, Thanendrarajan, Sharmilan, Zangari, Mauricio, van Rhee, Frits, Davies, Faith E., Sawyer, Jeffrey R., Morgan, Gareth J., Walker, Brian A.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6366829/
https://ncbi.nlm.nih.gov/pubmed/30774775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26589
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