Age- and genotype-dependent variability in the protein abundance and activity of six major uridine diphosphate-glucuronosyltransferases in human liver

The ontogeny of hepatic uridine diphosphate-glucuronosyltransferases (UGTs) was investigated by LC-MS/MS proteomics to determine UGT protein abundance in human liver microsomes isolated from 136 pediatric (0–18 years) and 35 adult (age 18–67 years) donors. Microsomal protein abundances of UGT1A1, UG...

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Publicat a:Clin Pharmacol Ther
Autors principals: Bhatt, Deepak Kumar, Mehrotra, Aanchal, Gaedigk, Andrea, Chapa, Revathi, Basit, Abdul, Zhang, Haeyoung, Choudhari, Prachi, Boberg, Mikael, Pearce, Robin E., Gaedigk, Roger, Broeckel, Ulrich, Leeder, J. Steven, Prasad, Bhagwat
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6222000/
https://ncbi.nlm.nih.gov/pubmed/29737521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1109
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