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Age- and genotype-dependent variability in the protein abundance and activity of six major uridine diphosphate-glucuronosyltransferases in human liver
The ontogeny of hepatic uridine diphosphate-glucuronosyltransferases (UGTs) was investigated by LC-MS/MS proteomics to determine UGT protein abundance in human liver microsomes isolated from 136 pediatric (0–18 years) and 35 adult (age 18–67 years) donors. Microsomal protein abundances of UGT1A1, UG...
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| Wydane w: | Clin Pharmacol Ther |
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| Główni autorzy: | , , , , , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2018
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6222000/ https://ncbi.nlm.nih.gov/pubmed/29737521 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1109 |
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