Mutant UBQLN2 promotes toxicity by modulating intrinsic self-assembly

UBQLN2 is one of a family of proteins implicated in ubiquitin-dependent protein quality control and integrally tied to human neurodegenerative disease. Whereas wild-type UBQLN2 accumulates in intraneuronal deposits in several common age-related neurodegenerative diseases, mutations in the gene encod...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Sharkey, Lisa M., Safren, Nathaniel, Pithadia, Amit S., Gerson, Julia E., Dulchavsky, Mark, Fischer, Svetlana, Patel, Ronak, Lantis, Gabrielle, Ashraf, Naila, Kim, John H., Meliki, Alia, Minakawa, Eiko N., Barmada, Sami J., Ivanova, Magdalena I., Paulson, Henry L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2018
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217421/
https://ncbi.nlm.nih.gov/pubmed/30333186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1810522115
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