Mutant UBQLN2 promotes toxicity by modulating intrinsic self-assembly

UBQLN2 is one of a family of proteins implicated in ubiquitin-dependent protein quality control and integrally tied to human neurodegenerative disease. Whereas wild-type UBQLN2 accumulates in intraneuronal deposits in several common age-related neurodegenerative diseases, mutations in the gene encod...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Sharkey, Lisa M., Safren, Nathaniel, Pithadia, Amit S., Gerson, Julia E., Dulchavsky, Mark, Fischer, Svetlana, Patel, Ronak, Lantis, Gabrielle, Ashraf, Naila, Kim, John H., Meliki, Alia, Minakawa, Eiko N., Barmada, Sami J., Ivanova, Magdalena I., Paulson, Henry L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2018
Konular:
PNAS Plus
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217421/
https://ncbi.nlm.nih.gov/pubmed/30333186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1810522115
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