GENE-03. WILD-TYPE Tp53 UNDERGOES A CELL TYPE-SPECIFIC INACTIVATION BY SIRT1 IN DE NOVO GLIOBLASTOMA

In contrast to most solid tumors, the majority (72%) of de novo glioblastoma (GBM) retain a wild-type Tp53 gene while undergoing loss of CDKN2A (INK4a/Arf locus). Remarkably, transcriptional and proteomic data suggest that Tp53 is abundantly expressed in de novo GBM; however, it appears not to confe...

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Publicado en:Neuro Oncol
Main Authors: Li, Li, Vemireddy, Vamsidhara, Goodarzi, Mohammad, Mashimo, Tomoyuki, Billman, Tara, Hatanpaa, Kimmo, Mickey, Bruce, Maher, Elizabeth, Bachoo, Robert, Piccirillo, Sara
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216443/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.430
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