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GENE-03. WILD-TYPE Tp53 UNDERGOES A CELL TYPE-SPECIFIC INACTIVATION BY SIRT1 IN DE NOVO GLIOBLASTOMA
In contrast to most solid tumors, the majority (72%) of de novo glioblastoma (GBM) retain a wild-type Tp53 gene while undergoing loss of CDKN2A (INK4a/Arf locus). Remarkably, transcriptional and proteomic data suggest that Tp53 is abundantly expressed in de novo GBM; however, it appears not to confe...
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| 出版年: | Neuro Oncol |
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| 主要な著者: | , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6216443/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.430 |
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