TNFα and Radioresistant Stromal Cells Are Essential for Therapeutic Efficacy of Cyclic Dinucleotide STING Agonists in Nonimmunogenic Tumors

The cGAS-STING cytosolic DNA sensing pathway may play an integral role in the initiation of antitumor immune responses. Studies evaluating the immunogenicity of various cyclic dinucleotide (CDN) STING agonists administered by intratumoral (i.t.) injection showed potent induction of inflammation, tum...

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Detaylı Bibliyografya
Yayımlandı:Cancer Immunol Res
Asıl Yazarlar: Francica, Brian J., Ghasemzadeh, Ali, Desbien, Anthony L., Theodros, Debebe, Sivick, Kelsey E., Reiner, Gabrielle L., Glickman, Laura Hix, Marciscano, Ariel E., Sharabi, Andrew B., Leong, Meredith L., McWhirter, Sarah M., Dubensky, Thomas W., Pardoll, Drew M., Drake, Charles G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6215542/
https://ncbi.nlm.nih.gov/pubmed/29472271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-17-0263
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