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Cyclic dinucleotide-adjuvanted dengue virus nonstructural 1 protein induces protective antibody and T-cell responses

Endothelial dysfunction and vascular leak, pathogenic hallmarks of severe dengue disease, are directly triggered by the dengue virus (DENV) nonstructural protein 1 (NS1). Previous studies have shown that immunization with NS1, as well as passive transfer of NS1-immune serum or anti-NS1 monoclonal an...

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Détails bibliographiques
Publié dans:J Immunol
Auteurs principaux: Espinosa, Diego A., Beatty, P. Robert, Reiner, Gabrielle L., Sivick, Kelsey E., Glickman, Laura Hix, Dubensky, Thomas W., Harris, Eva
Format: Artigo
Langue:Inglês
Publié: 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6363872/
https://ncbi.nlm.nih.gov/pubmed/30642979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1801323
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