TNFα and Radioresistant Stromal Cells Are Essential for Therapeutic Efficacy of Cyclic Dinucleotide STING Agonists in Nonimmunogenic Tumors

The cGAS-STING cytosolic DNA sensing pathway may play an integral role in the initiation of antitumor immune responses. Studies evaluating the immunogenicity of various cyclic dinucleotide (CDN) STING agonists administered by intratumoral (i.t.) injection showed potent induction of inflammation, tum...

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Udgivet i:Cancer Immunol Res
Main Authors: Francica, Brian J., Ghasemzadeh, Ali, Desbien, Anthony L., Theodros, Debebe, Sivick, Kelsey E., Reiner, Gabrielle L., Glickman, Laura Hix, Marciscano, Ariel E., Sharabi, Andrew B., Leong, Meredith L., McWhirter, Sarah M., Dubensky, Thomas W., Pardoll, Drew M., Drake, Charles G.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6215542/
https://ncbi.nlm.nih.gov/pubmed/29472271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-17-0263
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