Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity

Spontaneous tumor-initiated T cell priming is dependent on IFN-β production by tumor-resident dendritic cells. Based on recent observations indicating that IFN-β expression was dependent upon activation of the host STING pathway, we hypothesized that direct engagement of STING through intratumoral a...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Cell Rep
Huvudupphovsmän: Corrales, Leticia, Glickman, Laura Hix, McWhirter, Sarah M., Kanne, David B., Sivick, Kelsey E., Katibah, George E., Woo, Seng-Ryong, Lemmens, Edward, Banda, Tamara, Leong, Justin J., Metchette, Ken, Dubensky, Thomas W., Gajewski, Thomas F.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4440852/
https://ncbi.nlm.nih.gov/pubmed/25959818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.04.031
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk