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Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity
Spontaneous tumor-initiated T cell priming is dependent on IFN-β production by tumor-resident dendritic cells. Based on recent observations indicating that IFN-β expression was dependent upon activation of the host STING pathway, we hypothesized that direct engagement of STING through intratumoral a...
Zapisane w:
| Wydane w: | Cell Rep |
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| Główni autorzy: | , , , , , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2015
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4440852/ https://ncbi.nlm.nih.gov/pubmed/25959818 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.04.031 |
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