Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity

Spontaneous tumor-initiated T cell priming is dependent on IFN-β production by tumor-resident dendritic cells. Based on recent observations indicating that IFN-β expression was dependent upon activation of the host STING pathway, we hypothesized that direct engagement of STING through intratumoral a...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Corrales, Leticia, Glickman, Laura Hix, McWhirter, Sarah M., Kanne, David B., Sivick, Kelsey E., Katibah, George E., Woo, Seng-Ryong, Lemmens, Edward, Banda, Tamara, Leong, Justin J., Metchette, Ken, Dubensky, Thomas W., Gajewski, Thomas F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4440852/
https://ncbi.nlm.nih.gov/pubmed/25959818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.04.031
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