STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade

Stimulator of interferon genes (STING) is a cytosolic receptor that senses both exogenous and endogenous cytosolic cyclic dinucleotides (CDNs), activating TBK1/IRF3 (interferon regulatory factor 3), NF-κB (nuclear factor κB), and STAT6 (signal transducer and activator of transcription 6) signaling p...

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Vydáno v:Sci Transl Med
Hlavní autoři: Fu, Juan, Kanne, David B., Leong, Meredith, Glickman, Laura Hix, McWhirter, Sarah M., Lemmens, Edward, Mechette, Ken, Leong, Justin J., Lauer, Peter, Liu, Weiqun, Sivick, Kelsey E., Zeng, Qi, Soares, Kevin C., Zheng, Lei, Portnoy, Daniel A., Woodward, Joshua J., Pardoll, Drew M., Dubensky, Thomas W., Kim, Young
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4504692/
https://ncbi.nlm.nih.gov/pubmed/25877890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaa4306
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