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STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade

Stimulator of interferon genes (STING) is a cytosolic receptor that senses both exogenous and endogenous cytosolic cyclic dinucleotides (CDNs), activating TBK1/IRF3 (interferon regulatory factor 3), NF-κB (nuclear factor κB), and STAT6 (signal transducer and activator of transcription 6) signaling p...

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Bibliographische Detailangaben
Veröffentlicht in:Sci Transl Med
Hauptverfasser: Fu, Juan, Kanne, David B., Leong, Meredith, Glickman, Laura Hix, McWhirter, Sarah M., Lemmens, Edward, Mechette, Ken, Leong, Justin J., Lauer, Peter, Liu, Weiqun, Sivick, Kelsey E., Zeng, Qi, Soares, Kevin C., Zheng, Lei, Portnoy, Daniel A., Woodward, Joshua J., Pardoll, Drew M., Dubensky, Thomas W., Kim, Young
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4504692/
https://ncbi.nlm.nih.gov/pubmed/25877890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaa4306
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