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STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade
Stimulator of interferon genes (STING) is a cytosolic receptor that senses both exogenous and endogenous cytosolic cyclic dinucleotides (CDNs), activating TBK1/IRF3 (interferon regulatory factor 3), NF-κB (nuclear factor κB), and STAT6 (signal transducer and activator of transcription 6) signaling p...
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| Veröffentlicht in: | Sci Transl Med |
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4504692/ https://ncbi.nlm.nih.gov/pubmed/25877890 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaa4306 |
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