Cyclic dinucleotide-adjuvanted dengue virus nonstructural 1 protein induces protective antibody and T-cell responses

Endothelial dysfunction and vascular leak, pathogenic hallmarks of severe dengue disease, are directly triggered by the dengue virus (DENV) nonstructural protein 1 (NS1). Previous studies have shown that immunization with NS1, as well as passive transfer of NS1-immune serum or anti-NS1 monoclonal an...

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Vydáno v:J Immunol
Hlavní autoři: Espinosa, Diego A., Beatty, P. Robert, Reiner, Gabrielle L., Sivick, Kelsey E., Glickman, Laura Hix, Dubensky, Thomas W., Harris, Eva
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6363872/
https://ncbi.nlm.nih.gov/pubmed/30642979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1801323
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